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CD154 (CD40 Ligand) Mouse anti-Cynomolgus Monkey, Human, Clone: 24-31, eBioscience™

Mouse Monoclonal Antibody

Marke:  Affymetrix eBioscience 14-1548-80

Weitere Details : Netto-Gewicht : 0.01000kg

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Artikelnummer. 15267257

  • 86.75 € / 25 Mikrogramm

Verfügbar ab
25-05-2021

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Beschreibung

Beschreibung

Description: The 24-31 monoclonal antibody reacts with human CD154, a 39 kDa transmembrane glycoprotein also known as gp39 and CD40 ligand (CD40L). CD154 is a member of the TNF superfamily and is expressed transiently by activated T cells. Through its binding to CD40 on antigen presenting cells including B cells, monocytes/macrophages and dendritic cells, CD154 serves a crucial function in T-APC cognate interaction. CD154 interaction with CD40 transduces signals for T-dependent B-cell activation and induces B cell cycle entry. 24-31 cross-reacts with the cynomolgus monkey CD154. Applications Reported: 24-31 has been reported for use in flow cytometric analysis. 24-31 has also been reported to block CD154 binding to CD40 and inhibit T cell-dependent B cell differentiation and antibody response in vitro . (Please use Functional Grade Purified 24-31, cat. 16-1548, in functional assays.). Applications Tested: The 24-31 antibody has been tested by flow cytometric analysis of resting and activated human normal human peripheral blood cells. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. The CD40 Ligand stimulates B cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL-2.
Spezifikation

Spezifikation

CD154 (CD40 Ligand)
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P29965
RP23-153G22.3, CD154, CD40-L, Cd40l, HIGM1, IGM, IMD3, Ly-62, Ly62, T-BAM, TRAP, Tnfsf5, gp39, T-cell antigen Gp39, TNF-related activation protein, tumor necrosis factor ligand superfamily member 5
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Cynomolgus Monkey, Human
Flow Cytometry, Functional Assay, Neutralization
24-31
Unconjugated
CD40LG
Liquid
CD40LG
IgG1, kappa
25 μg
4° C
Primary
102138630, 959
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.