Learn More
CD274 (PD-L1, B7-H1) Monoclonal Antibody (MIH1), Alexa Fluor™ 488, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
315.00 €
Spezifikation
Antigen | CD274 (PD-L1, B7-H1) |
---|---|
Klon | MIH1 |
Konzentration | 5 μl/Test |
Anwendungen | Flow Cytometry |
Klassifikation | Monoclonal |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
---|---|---|---|---|---|---|---|---|---|
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
16321004
|
Affymetrix eBioscience
53-5983-42 |
100 Tests |
315.00 €
100 Tests |
Lager vorrätigLoggen Sie sich ein, um den Lagerbestand zu sehen | Bitte melden Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute! | ||||
Beschreibung
Description: The MIH1 monoclonal antibody reacts with human B7-H1, also known as PD-L1. B7-H1, a member of the B7 family, has a predicted molecular weight of approximately 40 kDa and belongs to the Ig superfamily. B7-H1 is expressed on a majority of leukocytes. B7-H1 is a ligand for PD-1. Interaction of PD-1 with either PD-L1 (B7-H1) or PD-L2 (B7-DC) results in inhibition of T and B cell responses. MIH1 is reported to be a blocking antibody. Applications Reported: This MIH1 antibody has been reported for use in flow cytometric analysis. Applications Tested: This MIH1 antibody has been pre-diluted and tested by flow cytometric analysis of stimulated normal human peripheral blood cells. This may be used at 5 μL (0.25 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488 nm; Emission: 519 nm; Laser: Blue Laser
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.Spezifikation
CD274 (PD-L1, B7-H1) | |
5 μl/Test | |
Monoclonal | |
Liquid | |
RUO | |
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2 | |
PD-L1 | |
CD274 | |
Primary | |
4° C, store in dark, DO NOT FREEZE! | |
CD274 |
MIH1 | |
Flow Cytometry | |
Alexa Fluor 488 | |
Mouse | |
Human | |
Q9NZQ7 | |
29126 | |
IgG1 κ | |
Affinity Chromatography | |
Antibody |