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CD278 (ICOS) Rat anti-Mouse, APC, Clone: 7E.17G9, eBioscience™

Rat Monoclonal Antibody

Marke:  Invitrogen 17-9942-82

Weitere Details : Netto-Gewicht : 0.01000kg

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Artikelnummer. 15913234

  • 252.00 € / 100 Mikrogramm
Voraussichtliches Versanddatum: 14-12-2021

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Beschreibung

Beschreibung

Description: The 7E.17G9 monoclonal antibody reacts with mouse ICOS (Inducible COStimulatory molecule), a T cell specific molecule and a third member of the CD28/CTLA-4 family. A homodimer of 47-57 kDa, ICOS is expressed on activated T cells, has potent costimulatory activity for T cell activation and proliferation and is required for humoral immune response. ICOS binds to its ligand on activated APC including B cells called B7h/B7RP-1 and is thought to play a protective role in inflammatory autoimmune diseases. ICOS may be involved in the development of Th2 cells. Applications Reported: This 7E.17G9 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 7E.17G9 antibody has been tested by flow cytometric analysis of stimulated mouse splenocytes. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser

CD278 belongs to the CD28 and CTLA-4 cell-surface receptor family and is highly expressed in activated T-cells. It is essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. It enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells.
Spezifikation

Spezifikation

CD278 (ICOS)
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
Q9WVS0
Icos
IgG2b, kappa
100 μg
4° C, store in dark, DO NOT FREEZE!
Primary
54167
Flow Cytometry
7E.17G9
APC
Icos
Liquid
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate
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