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CD366 (TIM3) Monoclonal Antibody (RMT3-23), APC, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Marke:  Affymetrix eBioscience 17-5870-82

213.34 EUR gültig bis 2024-03-29
Benutzen Sie den Promotions-Code "21615" um Ihren Promotions-Preis zu erhalten.



Weitere Details : Netto-Gewicht : 0.01000kg

Artikelnummer. 15805363

  • 320.00 € / 100 Mikrogramm
Verfügbar ab: 15-04-2024
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Beschreibung

Beschreibung

Description: The RMT3-23 monoclonal antibody reacts with mouse CD366 (TIM3), a Th1-specific cell surface protein. The RMT3-23 antibody reacts with CD366 protein expressed by both BALB/c and C57BL/6 strains of mice. CD366, a type I transmembrane protein, contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. CD366 is expressed selectively by differentiated CD4^+Th1 and CD8^+Tc1 cells, but is absent on CD4^+Th2 and CD8^+Tc2 cells. Other hematopoietic cell types, including naive T cells, B cells, macrophages and dendritic cells, do not express CD366, at least at the protein level. CD366 expression is upregulated at a late stage of T cell differentiation on Th1 cells after 3 rounds of in vitro polarization suggesting a role for this molecule in the transport or effector function of Th1 cells rather than a contribution to T cell differentiation. In an experimental autoimmune encephalomyelitis (EAE) model, CD366 was shown to be expressed on most CD4^+ and CD8^+ T cells in the central nervous system at the onset of clinical signs of disease, while less than 2% of CD4^+ cells in the periphery expressed CD366 after immunization. Applications Reported: This RMT3-23 antibody has been reported for use in flow cytometric analysis. Applications Tested: This RMT3-23 antibody has been tested by flow cytometric analysis of mouse splenocytes.

CD366 (TIM3) Monoclonal antibody specifically detects CD366 (TIM3) in Mouse samples. It is validated for Flow Cytometry.
Spezifikation

Spezifikation

CD366 (TIM3)
Monoclonal
0.2 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q8VIM0
Havcr2
Affinity chromatography
RUO
171285
4° C, store in dark, DO NOT FREEZE!
Liquid
Flow Cytometry
RMT3-23
APC
Havcr2
CD366; FLJ14428; Havcr2; HAVcr-2; Hepatitis A virus cellular receptor 2; hepatitis A virus cellular receptor 2 homolog; kidney injury molecule-3; KIM-3; sCD366; soluble CD366; soluble TIM 3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain containing 3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin family member 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; Tim3; TIM-3; TIMD3; TIMD-3
Rat
100 μg
Primary
Mouse
Antibody
IgG2a κ
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote