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CD54 (ICAM-1) Monoclonal Antibody (eBioKAT-1 (KAT-1, KAT1)), Functional Grade, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
114.00 € - 352.00 €
Spezifikation
Antigen | CD54 (ICAM-1) |
---|---|
Konzentration | 1 mg/mL |
Anwendungen | Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunoprecipitation, Neutralization |
Klassifikation | Monoclonal |
Konjugat | Functional Grade |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
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Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
15278477
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Affymetrix eBioscience
16-0542-85 |
500 μg |
352.00 €
500 Mikrogramm |
Verfügbar ab: 24-05-2024 Loggen Sie sich ein, um den Lagerbestand zu sehen |
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15258477
|
Affymetrix eBioscience
16-0542-81 |
50 μg |
Dieser Artikel ist im Moment nicht verfügbar oder wird nicht mehr hergestellt. Schauen Sie bitte auf unsere Produktseite nach möglichen Alternativen |
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Beschreibung
Description: The eBioKAT-1 monoclonal antibody reacts with mouse CD54 (ICAM-1), which is a 95 kDa member of the immunoglobulin superfamily. CD54 is expressed at low levels on leukocytes and high endothelial venules, and expression increases in response to inflammatory cytokines. ICAM-1 binds to LFA-1 and this interaction is required for the transendothelial migration of T cells. ICAM-1-deficient mice are viable, however the migration of leukocytes to sites of inflammation is reduced leading to impaired immune and inflammatory responses. Based on the regulated expression of ICAM-1, it has been suggested that ICAM-1 may increase leukocyte extravasation at sites of inflammation, whereas the constitutively high expression of ICAM-2 mediates leukocyte traffic into non-inflamed tissue. The eBioKAT-1 monoclonal antibody recognizes a different epitope than the YN1/1.7.4 monoclonal antibody. Applications Reported: This eBioKAT-1 (KAT-1, KAT1) antibody has been reported for use in flow cytometric analysis, immunoprecipitation, and immunohistology staining of frozen tissue sections. The KAT-1 monoclonal antibody has also been reported to inhibit the in vivo ICAM-1-mediated migration of leukocytes. Applications Tested: This eBioKAT-1 (KAT-1, KAT1) antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.5 μg per test.
ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.Spezifikation
CD54 (ICAM-1) | |
Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunoprecipitation, Neutralization | |
Functional Grade | |
Rat | |
Mouse | |
P13597 | |
IgG2a κ | |
Affinity chromatography | |
Antibody |
1 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
PBS with no preservative; pH 7.2 | |
15894 | |
Primary | |
4° C |
For Research Use Only.