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CD8 Mouse anti-Human, APC-Cy7, Clone: SK1, BD
Mouse Monoclonal Antibody
257.00 € - 560.00 €
Spezifikation
| Antigen | CD8 |
|---|---|
| Klon | SK1 |
| Anwendungen | Flow Cytometry |
| Klassifikation | Monoclonal |
| Konjugat | APC-Cyanine7 |
| Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
|---|---|---|---|---|---|---|---|---|---|
| Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
|
15801499
|
BD Biosciences
561945 |
25 Tests |
257.00 €
1 Stück |
Verfügbar ab: 21-05-2024 Loggen Sie sich ein, um den Lagerbestand zu sehen |
Bitte melden Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute! | ||||
|
15879068
|
BD Biosciences
557834 |
100 Tests |
560.00 €
1 Stück |
Verfügbar ab: 13-05-2024 Loggen Sie sich ein, um den Lagerbestand zu sehen |
Bitte melden Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute! | ||||
Beschreibung
The SK1 monoclonal antibody specifically binds to CD8 alpha (CD8α). CD8α is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. CD8α is expressed by the majority of thymocytes, by subpopulations of αβ T cells and γδ T cells and by some NK cells. Cell surface CD8α is expressed either as a disulfide-linked homodimer (CD8αα) or as a heterodimer (CD8αβ) when disulfide-bonded to a CD8 beta chain (CD8β). CD8-positive αβ T cells coexpress both CD8αα homodimers and CD8αβ heterodimers whereas some γδ T cells and NK cells express CD8αα homodimers. CD8 plays important roles in T cell activation and selection. The extracellular IgSF domain of CD8α binds to a non-polymorphic determinant on HLA class I molecules (α3 domain) and enables CD8 to function as a co-receptor with MHC class I-restricted TCR during T cell recognition of antigen. The cytoplasmic domain of CD8α associates with Lck, a Src family protein tyrosine kinase that is involved in intracellular signaling.
Spezifikation
| CD8 | |
| Flow Cytometry | |
| APC-Cyanine7 | |
| RUO | |
| Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
| IgG1 κ | |
| Affinity Purified | |
| CD8α; CD8A; CD8 alpha; Leu2a; MAL; T8; p32 |
| SK1 | |
| Monoclonal | |
| Mouse | |
| Baboon, Cynomolgus, Human, Rhesus Monkey | |
| Human Peripheral Blood T Cells | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
For Research Use Only.