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Invitrogen™ CDK2 Monoclonal Antibody (10-D7)

Beschreibung
CDK2 Monoclonal Antibody for ICC/IF, Western Blot
CDK2/cyclinO is a member of the cyclin dependent protein kinase family complexed to CyclinO. CyclinO was used as a specific protein isoform name for the UNG gene which is localized exclusively in the nucleus. In addition, CyclinO was reported to shows significant uracil-DNA glycosylase activity. CDK2/cyclinO protein levels increase during G1 phase and the protein is turned over during the course of cell cycle. The levels of cyclin A-cdk2 is maximal at the G1/S transition and both cdk2 and cyclin A are found associated with DNA in the initiation complex during replication. Rb protein acts as substrate for cdk2-cyclin E and/or cdk2-cyclin A in vivo. Cdk2 is activated and specifically localized to the nucleus during late G1-, S-, and G2-phase.
Spezifikation
Spezifikation
| Antigen | CDK2 |
| Anwendungen | Western Blot, Immunocytochemistry, Western Blot |
| Klassifikation | Monoclonal |
| Klon | 10-D7 |
| Konzentration | 2 mg/mL |
| Konjugat | Unconjugated |
| Zusammensetzung | PBS with 40% Glycerol, 0.2% BSA and 0.05% sodium azide; pH 7.4 |
| Gen | CDK2 |
| Gen-Zugriffsnummer | P24941, P97377, Q63699 |
| Gen-Alias | A630093N05Rik; CDC28; CDC2A; cdc2-related protein kinase; CDK1; CDK2; CDKN2; Cell division protein kinase 2; cyclin dependent kinase 2; cyclin dependent kinase 2-alpha; cyclin-dependent kinase 2; EC 2.7.11.22; EC 2.7.11.23; kinase Cdc2; MPF; p33 protein kinase; p33(CDK2); p33CDK2; p34 protein kinase |
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