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Invitrogen™ CDK4/cyclin D3 Recombinant Human Protein

Dieses rekombinante humane CDK4/Cyclin D3-Protein (CDK4: volle Länge, Cyclin D3: volle Länge) wurde in Insektenzellen exprimiert.

Marke:  Invitrogen™ A33515

Weitere Details : Netto-Gewicht : 0.01000kg

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Artikelnummer. 15900423

  • 468.00 € / 10 Mikrogramm
Verfügbar ab: 20-12-2022
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Beschreibung

Beschreibung

  • This CDK4/cyclin D3 recombinant human protein (CDK4: full length, cyclin D3: full length) was expressed in insect cells
  • CDK4/cyclin D3 serine/threonine kinase is a dimeric protein complex
  • CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle
  • It forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2)
  • CDK4 can mediate phosphorylation of the C-terminal region of Rb protein, leading to an active transcriptional repression of E2F complex
  • CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins
  • SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2
  • Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivities in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein
  • CDK4/cyclin D3 recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service
  • Validated for use with the Adapta™ assay
  • Available in multiple pack sizes for convenient use
Spezifikation

Spezifikation

CDK4: NP_000066.1, Cyclin D3: NP_001751.1
10 µg
CDK4: Full Length, Cyclin D3: Full Length
GST Tag
Dry Ice
Kinases & Inhibitors
Liquid
Human
60.0/58.8 kDa
CDKs and CHKs
Yes
Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.25 mM DTT, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol
Baculovirus
Full Length, Recombinant, Active
Kinase Assay
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate
Sonderangebote

Sonderangebote