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Invitrogen™ Human CDK4/cyclin D3, GST Tag Recombinant Protein
Human CDK4/cyclin D3, GST Tag Recombinant Protein
Marke: Invitrogen™ A33515
Weitere Details : Netto-Gewicht : 0.01000kg
Beschreibung
- This CDK4/cyclin D3 recombinant human protein (CDK4: full length, cyclin D3: full length) was expressed in insect cells
- CDK4/cyclin D3 serine/threonine kinase is a dimeric protein complex
- CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle
- It forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2)
- CDK4 can mediate phosphorylation of the C-terminal region of Rb protein, leading to an active transcriptional repression of E2F complex
- CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins
- SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2
- Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivities in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein
- CDK4/cyclin D3 recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service
- Validated for use with the Adapta™ assay
- Available in multiple pack sizes for convenient use
Spezifikation
| CDK4: NP_000066.1, Cyclin D3: NP_001751.1 | |
| 60.0/58.8 kDa | |
| CDKs and CHKs | |
| Human | |
| GST Tag | |
| Dry Ice | |
| Kinases & Inhibitors | |
| Liquid |
| Kinase Assay | |
| 10 μg | |
| CDK4: Full Length, Cyclin D3: Full Length | |
| Recombinant | |
| Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.25 mM DTT, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol | |
| Baculovirus | |
| Full Length, Recombinant, Active |