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CHIR 99021, Tocris Bioscience™

Highly selective GSK-3 inhibitor

Marke:  RD Systems (Bio-Techne) 4423/10

Weitere Details : Netto-Gewicht : 0.00010kg

Menge. 10mg

 Weitere Artikel aus diesem Sortiment

Artikelnummer. 13414734

  • 285.13 € / 10 Milligramm


Voraussichtlicher Liefertermin 29-03-2019
Zum Warenkorb hinzufügen

Beschreibung

Beschreibung

Potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3) (IC 50 values are 6.7 and 10 nM for GSK-3β and GSK-3α respectively). Exhibits >500-fold selectivity for GSK-3 over closely related kinases; also displays >800-fold selectivity against 45 additional enzymes and receptors. In combination with tranylcypromine (Cat. No. 3852), enables reprogramming of mouse embryonic fibroblasts, transduced by Oct4 and Klf4 only, into iPSCs. Enhances mouse and human ESC self-renewal when used in combination with PD 0325901 (Cat. No. 4192). Allows formation of extended pluripotent stem (EPS) cells in combination with (S)-(+)-Dimethindene maleate (Cat.No. 1425), minocycline hydrochloride (Cat.No. 3268) and human leukemia inhibitory factor. CHIR 99021 synthesized to cGMP guidelines also available.
Spezifikation

Chemische Identifikatoren

252917-06-9
465.342
gsk-3 inhibitor xvi, unii-234cmt4gk4, chir-911, 6-2-4-2,4-dichlorophenyl-5-4-methyl-1h-imidazol-2-yl pyrimidin-2-ylamino ethylamino pyridine-3-carbonitrile, 6-2-4-2,4-dichlorophenyl-5-4-methyl-1h-imidazol-2-yl pyrimidin-2-yl amino ethyl amino nicotinonitrile, 6-2-4-2,4-dichlorophenyl-5-4-methyl-1h-imidazol-2-yl pyrimidin-2-yl amino ethyl amino pyridine-3-carbonitrile, 6-2-4-2,4-dichlorophenyl-5-5-methyl-1h-imidazol-2-yl-2-pyrimidinyl amino ethyl amino-3-pyridinecarbonitrile, 3-pyridinecarbonitrile, 6-2-4-2,4-dichlorophenyl-5-5-methyl-1h-imidazol-2-yl-2-pyrimidinyl amino ethyl amino, 3-pyridinecarbonitrile, 6-2-4-2,4-dichlorophenyl-5-5-methyl-1h-imidazol-2-yl-2-pyrimidinyl amino ethyl amino, 6-2-4-2,4-dichlorophenyl-5-5-methyl-1h-imidazol-2-yl pyrimidin-2-yl amino ethyl amino nicotinonitrile
6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile
C22H18Cl2N8
AQGNHMOJWBZFQQ-UHFFFAOYSA-N
9956119
CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N

Spezifikation

CHIR 99021
252917-06-9
gsk-3 inhibitor xvi, unii-234cmt4gk4, chir-911, 6-2-4-2,4-dichlorophenyl-5-4-methyl-1h-imidazol-2-yl pyrimidin-2-ylamino ethylamino pyridine-3-carbonitrile, 6-2-4-2,4-dichlorophenyl-5-4-methyl-1h-imidazol-2-yl pyrimidin-2-yl amino ethyl amino nicotinonitrile, 6-2-4-2,4-dichlorophenyl-5-4-methyl-1h-imidazol-2-yl pyrimidin-2-yl amino ethyl amino pyridine-3-carbonitrile, 6-2-4-2,4-dichlorophenyl-5-5-methyl-1h-imidazol-2-yl-2-pyrimidinyl amino ethyl amino-3-pyridinecarbonitrile, 3-pyridinecarbonitrile, 6-2-4-2,4-dichlorophenyl-5-5-methyl-1h-imidazol-2-yl-2-pyrimidinyl amino ethyl amino, 3-pyridinecarbonitrile, 6-2-4-2,4-dichlorophenyl-5-5-methyl-1h-imidazol-2-yl-2-pyrimidinyl amino ethyl amino, 6-2-4-2,4-dichlorophenyl-5-5-methyl-1h-imidazol-2-yl pyrimidin-2-yl amino ethyl amino nicotinonitrile
CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N
465.342
465.34
10mg
C22H18Cl2N8
AQGNHMOJWBZFQQ-UHFFFAOYSA-N
6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile
9956119
>99%
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