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DMH-1, Tocris Bioscience™

Selective ALK2 inhibitor

Marke:  Tocris (Bio-Techne) 412650

Weitere Details : Netto-Gewicht : 0.01000kg

Menge. 50mg

 Weitere Artikel aus diesem Sortiment

Artikelnummer. 13414204

  • 1014.99 € / 50 Milligramm


Voraussichtlicher Liefertermin 31-07-2019
Zum Warenkorb hinzufügen

Beschreibung

Beschreibung

Selective inhibitor of bone morphogenic protein (BMP) type-I receptor activin receptor-like kinase 2 (ALK2) receptor (IC50 = 108 nM [Hao et al., 2010] or 12.6 nM [Mohedas et al., 2013] in in vitro kinase assays). Exhibits 6- and 19-fold selectivity for ALK-2 over ALK-1 and ALK-3, respectively, and no significant inhibition of AMPK, ALK5, KDR (VEGFR-2) or PDGFRβ receptors. Blocks BMP4-induced phosphorylation of Smads 1, 5 and 8 in HEK293 cells. Promotes neurogenesis in human induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. No. 1614).
Spezifikation

Chemische Identifikatoren

1206711-16-1
380.451
dmh-1, dmh1, dmh 1, 4-6-4-propan-2-yloxyphenyl pyrazolo 1,5-a pyrimidin-3-yl quinoline, 4-6-4-1-methylethoxy phenyl pyrazolo 1,5-a pyrimidin-3-yl-quinoline, 4-6-4-isopropoxyphenyl pyrazolo 1,5-a pyrimidin-3-yl quinoline, 4-6-4-propan-2-yl oxy phenyl pyrazolo 1,5-a pyrimidin-3-yl quinoline, dmh hplc, 4-6-4-isopropoxyphenyl pyrazolo 1,5-a pyrimidin-3-yl quinoline, quinoline, 4-6-4-1-methylethoxy phenyl pyrazolo 1,5-a pyrimidin-3-yl
CHEBI:86289
CC(C)OC1=CC=C(C=C1)C2=CN3C(=C(C=N3)C4=CC=NC5=CC=CC=C45)N=C2
C24H20N4O
JMIFGARJSWXZSH-UHFFFAOYSA-N
50997747
4-[6-(4-propan-2-yloxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline

Spezifikation

DMH-1
1206711-16-1
dmh-1, dmh1, dmh 1, 4-6-4-propan-2-yloxyphenyl pyrazolo 1,5-a pyrimidin-3-yl quinoline, 4-6-4-1-methylethoxy phenyl pyrazolo 1,5-a pyrimidin-3-yl-quinoline, 4-6-4-isopropoxyphenyl pyrazolo 1,5-a pyrimidin-3-yl quinoline, 4-6-4-propan-2-yl oxy phenyl pyrazolo 1,5-a pyrimidin-3-yl quinoline, dmh hplc, 4-6-4-isopropoxyphenyl pyrazolo 1,5-a pyrimidin-3-yl quinoline, quinoline, 4-6-4-1-methylethoxy phenyl pyrazolo 1,5-a pyrimidin-3-yl
CC(C)OC1=CC=C(C=C1)C2=CN3C(=C(C=N3)C4=CC=NC5=CC=CC=C45)N=C2
380.451
CHEBI:86289
>98%
50mg
C24H20N4O
JMIFGARJSWXZSH-UHFFFAOYSA-N
4-[6-(4-propan-2-yloxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
50997747
380.44
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