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Invitrogen™ DR4 Polyclonal Antibody

Beschreibung
Immunogen sequence: PSSAATIKLH DQSIGTQQWE HSPLGELCPP GSHRS Highest antigen sequence indentity to the following orthologs: Rat - 37%, Mouse - 36%.
TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).
Spezifikation
Spezifikation
| Antigen | DR4 |
| Anwendungen | Immunohistochemistry (Paraffin), Immunocytochemistry |
| Klassifikation | Polyclonal |
| Konzentration | 0.05 mg/mL |
| Konjugat | Unconjugated |
| Zusammensetzung | PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 |
| Gen | TNFRSF10A |
| Gen-Zugriffsnummer | O00220 |
| Gen-Alias | APO2; CD261; cytotoxic TRAIL receptor; death receptor 4; DR4; MGC9365; sCD261; soluble CD261; soluble TRAIL; sTRAIL; TNF receptor superfamily member 10a; TNF-related apoptosis-inducing ligand receptor 1; TNFRSF10A; TRAIL R1; TRAIL receptor 1; TRAILR1; TRAIL-R1; TRAILR-1; tumor necrosis factor receptor superfamily member 10A; tumor necrosis factor receptor superfamily member 10a variant 2; tumor necrosis factor receptor superfamily, member 10a |
| Gensymbole | TNFRSF10A |
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