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![EGFR (ErbB1) [L861Q] Recombinant Human Protein 10μg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-650.jpg)
EGFR (ErbB1) [L861Q] Recombinant Human Protein
EGFR (ErbB1) [L861Q] Recombinant Human Protein
Marke: Invitrogen PV3873
Weitere Details : Netto-Gewicht : 0.05250kg
Beschreibung
The epidermal growth factor receptor is a receptor tyrosine kinase that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The EGFR L861Q mutation is an Iressa-responsive mutant observed in the clinic.Spezifikation
| NP_005219.2; L861Q | |
| Pharma and Biopharma, Protein Assays and Analysis, Target and Lead Identification and Validation, Kinase Assay | |
| 90.5kDa | |
| 10μg | |
| For research use only. Not for use in diagnostic procedures | |
| EGFR (ErbB1) L861Q | |
| EGFR (ErbB1) L861Q was pre-diluted in enzyme dilution buffer and assayed in 25mM Tris (pH 7.5), 10mM MgCl2, 0.5mM EGTA, 0.5mM Na3VO4, 5mM β-glycerophosphate, 2.5mM DTT, 0.01% Triton™ X-100, 200μM ATP, 200μg/mL Abl1 peptide substrate (EAIYAAPFAKKK) and trace [32P]-γ-ATP for 10 minutes at 30°C | |
| Amino acids 668-1210: L858R, Amino acids 668-1210; L861Q | |
| 231nmoles of phosphate transferred to Abl1 peptide substrate (EAIYAAPFAKKK) per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 3.33μg/mL | |
| GST Tag | |
| Kinase and inhibitors | |
| 65% by SDS-PAGE |
| 0.33mg/mL | |
| 114294, 1956 | |
| EGFR (ErbB1) [L861Q] Recombinant Human Protein | |
| –80°C | |
| 1 Each | |
| EGFR (ErbB1) [L861Q] Recombinant Human Protein | |
| EGF receptor (ErbB) | |
| EGFR (ErbB1) [L861Q] Recombinant Human Protein | |
| Human | |
| Baculovirus | |
| Receptor tyrosine kinases |
For Research Use Only. Not for use in diagnostic procedures.