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  6. Invitrogen™ F4/80 Monoclonal Antibody (BM8), Functional Grade, eBioscience™, Invitrogen™

Invitrogen™ F4/80 Monoclonal Antibody (BM8), Functional Grade, eBioscience™, Invitrogen™
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Artikelnummer. p-7069880
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Menge:
1 mg
Packungsgröße:
1 Milligramm
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Artikelnummer. Menge unitSize
15278627 1 mg 1 Milligramm
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Artikelnummer. 15278627 Lieferant Invitrogen™ Lieferanten-Nr. 16480186

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Beschreibung

Rat Monoclonal Antibody

EGF-Like Module Containing Mucin-Like Hormone Receptor-Like Sequence 1 (EMR1) is characterized as an Orphan-B GPCR with an unknown ligand. The C-terminus contains seven hydrophobic segments, characteristic of a G protein-coupled receptor. The N-terminus of EMR1 has 6 EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. EMR1 has been reported to be expressed in human peripheral blood mononuclear cells, monocytes, and hematopoietic and solid tumor-derived cell lines. ESTs have been isolated from human normal spleen and mixed liver/spleen libraries and from human kidney, colon, brain, and bone marrow cancer libraries.

F4/80 antigen is a 160 kDa cell surface glycoprotein that is a member of the EGF TM7 family of proteins and shares 68% overall amino acid identity with human EGF module containing mucin like hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ve regulatory T cells.
TRUSTED_SUSTAINABILITY

Spezifikation

Antigen F4/80
Anwendungen Control, Flow Cytometry, Functional Assay
Klassifikation Monoclonal
Klon BM8
Konzentration 1 mg/mL
Konjugat Functional Grade
Zusammensetzung PBS with no preservative; pH 7.2
Gen ADGRE1
Gen-Zugriffsnummer Q61549
Gen-Alias ADGRE1; Adhesion G protein-coupled receptor E1; Adhesion G protein-coupled receptor E2; cell surface glycoprotein EMR1; cell surface glycoprotein F4/80; DD7A5-7; EGF-like module containing, mucin-like, hormone receptor-like 1; EGF-like module containing, mucin-like, hormone receptor-like sequence 1; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EGF-TM7; Emr1; EMR1 hormone receptor; F4/80; Gpf480; Ly71; lymphocyte antigen 71; TM7LN3
Gensymbole ADGRE1
Wirtsspezies Rat
Reinigungsverfahren Affinity Chromatography
Menge 1 mg
Regulatorischer Status RUO
Primär oder sekundär Primary
Gen-ID (Entrez) 13733
Zielspezies Mouse
Inhalt und Lagerung 4°C
Produkttyp Antibody
Form Liquid
Isotype IgG2a κ
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