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FceR1 alpha Mouse anti-Human, Biotin, Clone: AER-37 (CRA1), eBioscience™

Mouse Monoclonal Antibody

Marke:  Affymetrix eBioscience 13-5899-80

Weitere Details : Netto-Gewicht : 0.25000kg

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Artikelnummer. 15259919

  • 139.00 € / 25 Mikrogramm

Verfügbar ab
21-06-2021

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Beschreibung

Beschreibung

Description: The AER-37 monoclonal antibody reacts with the Fc epsilon RI alpha subunit, an IgE-binding subunit lacking signal-transducing ability. Fc epsilon RI apha is expressed on mast and basophil cells and is upregulated by the presence of IgE. Fc epsilon RI alpha forms a tetrameric complex with one beta and two gamma subunits. The beta and gamma subunits possess immunoreceptor tyrosine-based activation motifs (ITAM). The Fc epsilon RI complex plays an important role in triggering IgE-mediated allergic reactions. Applications Reported: AER-37 has been reported for use in flow cytometric analysis. Applications Tested: The AER-37 (CRA1) antibody has been tested by flow cytometric analysis of peripheral blood cells. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 μm post-manufacturing filtered.

FceR1 (Fc epsilonR1 alpha) is a subunit of the high affinity receptor of IgE. Fc epsilonR1 alpha is a tetrameric complex consisting of one alpha, one ß and two additional subunits. The latter two are required for signal transduction activity. The Fc epsilonR1 complex plays an important role in triggering allergic responses, and the immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine, which are responsible for allergy symptoms, are released. The IgE receptor couples allergen and mast cells to initiate the inflammatory responses that are characteristic of disorders such as hay fever and asthma. The release of histamine and proteases leads to the synthesis of prostaglandins and leukotrienes-potent effectors of the hypersensitivity response.
Spezifikation

Spezifikation

FceR1 alpha
Monoclonal
0.5 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P12319
RP11-550P17.3, FCE1A, FcERI
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
AER-37 (CRA1)
Biotin
FCER1A
Liquid
FCER1A
IgG2b, kappa
25 μg
4° C, do not freeze
Primary
2205
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.