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FOXP3 Rat anti-Chimpanzee, Cynomolgus Monkey, Human, Non-human primate, Rhesus Monkey, APC, Clone: PCH101, eBioscience™

Rat Monoclonal Antibody

Marke:  Affymetrix eBioscience 17-4776-42

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Artikelnummer. 11560617

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Beschreibung

Beschreibung

Applications Tested: This PCH101 antibody has been pre-titrated and tested by intracellular flow cytometric analysis of normal human peripheral blood cells using the Foxp3/Transcription Factor Buffer and protocol. Refer to Best Protocols for Staining Protocol (refer to Protocol B: One-step protocol for intracellular (nuclear) proteins). This can be used at 5 µL (0.5 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered. FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.
Spezifikation

Spezifikation

Foxp3
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
Q9BZS1
AIID, DIETER, Forkhead box P3, foxp3, IPEX, JM2, PIDX, SCURFIN, XPID
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Chimpanzee, Cynomolgus Monkey, Human, Non-human primate, Rhesus Monkey
Flow Cytometry
PCH101
APC
FOXP3
Liquid
FOXP3
IgG2a, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
102120882, 50943, 574303, 740909
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.