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Granzyme K Monoclonal Antibody (G3H69), PE, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Marke: Affymetrix eBioscience 12-8897-42
Weitere Details : Netto-Gewicht : 0.01000kg
Beschreibung
Description: This G3H69 monoclonal antibody reacts with human Granzyme K. Granzyme K is one of five granzyme serine proteases that have been indentified in humans. These proteins are expressed in the granules of NK cells and cytotoxic T cells, and are critical for the induction of target cell apoptosis through the cleavage of intracellular substrates. Granzyme A and Granzyme K are both tryptases and appear to show overlapping, though not identical, substrate specificity. This functional similarity is believed to account for the minimal decrease in cytotoxicity of Granzyme A-deficient CTLs. Applications Reported: This G3H69 antibody has been reported for use in flow cytometric analysis. Applications Tested: This G3H69 antibody has been pre-diluted and tested by flow cytometric analysis of stimulated normal human peripheral blood cells. This may be used at 5 μL (0.06 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser
Granzyme K (GrK) belongs to a family of trypsin-like serine proteases localised in the cytotoxic granules of activated T cells and NK cells. It encodes a 28 kDa serine protease whose gene is located on chromosome 5q11-12 close to the granzyme A-encoding gene. Like granzyme A, it has a trypsin-like specifity cleaving at the basic residues arginine and lysine. Granzyme K triggers rapid cell death independently of caspase activation with single-stranded DNA nicks and is primarily expressed in thymus, lung, spleen and peripheral blood leukocytes.Spezifikation
Granzyme K | |
Monoclonal | |
5 μl/Test | |
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2 | |
P49863 | |
GZMK | |
Affinity Chromatography | |
RUO | |
3003 | |
4° C, store in dark, DO NOT FREEZE! | |
Liquid |
Flow Cytometry | |
G3H69 | |
PE | |
GZMK | |
GZMK; TRYP2 | |
Mouse | |
100 Tests | |
Primary | |
Human | |
Antibody | |
IgG2a κ |