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Invitrogen™ HSD3B2 Polyclonal Antibody
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Artikelnummer. 16613335 Alle ansehen Thermo Scientific Produkte
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Menge:
100 μL
Packungsgröße:
100 Mikroliter
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16613335 100 μL 100 Mikroliter
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Artikelnummer. 16613335 Lieferant Invitrogen™ Lieferanten-Nr. PA5106895

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Beschreibung

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total HSD3B2.

3 beta-hydroxysteroid dehydrogenase (3beta-HSD), also known as HSD3B1 or HSDB3, is a bifunctional enzyme that plays a crucial role in the synthesis of all classes of hormonal steroids. Two human 3beta-HSD proteins, designated type I (3beta-HSD) and type II (3beta-HSD2), are expressed by different genes and function in different areas of the body. Localized to the membrane of the endoplasmic reticulum (ER) and expressed in skin and placenta, 3beta-HSD is the type I protein that catalyzes the oxidative conversion of delta5-ene-3-beta-hydroxy steroid, as well as the conversion of various ketosteroids. Defects in the gene encoding 3beta-HSD are associated with classic salt wasting, genital ambiguity, hypogonadism, insulin-resistant polycystic ovary syndrome (PCOS) and an increased susceptibility to prostate cancer. Additionally, congenital deficiency of 3beta-HSD activity results in a severe depletion of steroid formation which can be lethal in young children.
TRUSTED_SUSTAINABILITY

Spezifikation

Antigen HSD3B2
Anwendungen Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Klassifikation Polyclonal
Konzentration 1 mg/mL
Konjugat Unconjugated
Zusammensetzung PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gen HSD3B2
Gen-Zugriffsnummer P26149, P26439
Gen-Alias 3 beta HSD II; 3 beta-HSD type II; 3 beta-hydroxysteroid dehydrogenase 2; 3 beta-hydroxysteroid dehydrogenase 6; 3 beta-hydroxysteroid dehydrogenase type II, delta 5-delta 4-isomerase type II, 3 beta-HSD type II; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type IV; 3beta-HSD; 3-beta-HSD adrenal and gonadal type; 3-beta-HSD II; 3-beta-HSD IV; 3-beta-hydroxy-5-ene steroid dehydrogenase; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; delta 5-delta 4-isomerase type II; Delta-5-3-ketosteroid isomerase; HSD3B; Hsd3b1; Hsd3b2; Hsd3b6; HSD-3beta; HSDB; HSDB3B; Hydroxy-delta-5-steroid dehydrogenase 3 beta- and steroid delta-isomerase; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6; hydroxysteroid dehydrogenase-2, delta>5>-3-beta; hydroxysteroid dehydrogenase-6 delta>5>-3-beta; progesterone reductase; SDR11E2; short chain dehydrogenase/reductase family 11E, member 2; Steroid Delta-isomerase
Gensymbole HSD3B2
Wirtsspezies Rabbit
Immunogen A synthesized peptide derived from human HSD3B2(Accession P26439), corresponding to amino acid residues L108-K158.
Reinigungsverfahren Affinity chromatography
Menge 100 μL
Regulatorischer Status RUO
Primär oder sekundär Primary
Gen-ID (Entrez) 15493, 29632, 3284
Zielspezies Avian, Human, Mouse, Rat
Inhalt und Lagerung -20°C
Produkttyp Antibody
Form Liquid
Isotype IgG
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