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ACROBiosystems Human CD3 epsilon Protein, Fc,His Tag
Marke: ACROBiosystems CDE-H5256-1MG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
This protein carries a human IgG1 Fc tag at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 39.2 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
NP_000724.1 | |
1 mg | |
Asp 23 - Asp 126 | |
FLJ18683,T3E,TCRE,CD3E,CD3-epsilon | |
Unconjugated | |
His Tag and Fc Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |
39.2 kDa | |
Human CD3 epsilon, Fc,His Tag (CDE-H5256) is expressed from human 293 cells (HEK293). It contains AA Asp 23 - Asp 126 (Accession # NP_000724.1). | |
-20°C | |
CD3 epsilon | |
Human | |
PBS, pH7.4 | |
HEK293 | |
Bio-Markers and CD Antigens |