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ACROBiosystems Human CD40 / TNFRSF5 Protein, Mouse IgG2a Fc Tag, low endotoxin

MALS verified

Marke:  ACROBiosystems CD0-H525A-1MG

Weitere Details : Netto-Gewicht : 0.00001kg

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Artikelnummer. 15896127

  • 2486.22 € / 1 Milligramm
Verfügbar ab: 23-12-2022
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Beschreibung

Beschreibung

CD40 is also known as TNFRSF5, Bp50, CDW40, MGC9013, TNFRSF5 and p50, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins, and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 contains 4 cysteine-rich repeats in the extracellular domain, and is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines.

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 46.1 kDa. The protein migrates as 58 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

NP_001241.1
46.1 kDa
1 mg
Glu 21 - Arg 193
CD40,Bp50,CDW40,MGC9013,TNFRSF5,p50
Unconjugated
50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5
HEK293
Human
Powder
>95% as determined by SDS-PAGE
Human CD40, Mouse IgG2a Fc Tag, low endotoxin (MALS verified) (CD0-H525a) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Arg 193 (Accession # P25942-1).
-20°C
CD40
Mouse IgG Fc Tag
Less than 0.1 EU / µg by the LAL method.
Immune Checkpoint Proteins
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Sicherheitsdatenblatt (SDS)
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