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Gibco™ Human IFN-alpha A (alpha 2a) Recombinant Protein

Artikelnummer. 10180863
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Menge:
8.4 x 10^6 Einheiten
Packungsgröße:
1 Stück
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10180863 8.4 x 10^6 Einheiten 1 Stück
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Artikelnummer. 10180863 Lieferant Gibco™ Lieferanten-Nr. PHC4814

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Beschreibung

Recombinant Protein

Dilution Recommendation: Further dilutions should be made in medium or buffered solution containing carrier protein such as PBS with 0.1% BSA.

IFN alpha (Interferon alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins exclusive to vertebrates. The interaction of IFN-alpha with its receptor component result in the activation of a number of signaling pathways which are mainly involved in innate immune response against viral infection. In humans, the gene for IFN alpha is located on on chromosome 9. The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. IFN alpha is produced primarily by plasmacytoid dendritic cells, is a potent component of the anti-viral innate immune response and modulates adaptive immunity. Diseases associated with the dysfunction of IFN alpha include Hepatitis C and Hepatitis.
TRUSTED_SUSTAINABILITY

Spezifikation

Zugriffsnummer P01563
Zur Verwendung mit (Anwendung) Bioactivity
Zusammensetzung PBS with 0.1% BSA and no preservative
Gen-ID (Entrez) 3440
Molekulargewicht 19.2 kDa
Name Human IFN-alpha A (alpha 2a)
Reinigungsverfahren Purified
Menge 8.4 x 10^6 Einheiten
Lagerungsbedingungen -80°C
Kennzeichnung RUO
Gen-Alias alpha-2a interferon; Ifa2; IFNA; IFN-a; IFNA 2; Ifna2; IFNA2A; IFNA2B; IFNA2C; IFN-alpha 1b; IFN-alpha-1/13; IFN-alpha-2; IFN-alphaA; INFA2; Interferon; interferon alpha 1b; interferon alpha 2; interferon alpha 2a; interferon alpha 2b; interferon alpha A; interferon alpha family, gene 2; interferon alpha-2; Interferon alpha-A; interferon alpha-D; interferon, alpha 2; Interferon-alpha II; leIF A; leIF D; RP11-354P17.2
Gebräuchliche Bezeichnung Interferon alpha-2
Gensymbol IFNA2
Biologische Aktivität Specific activity = 4.0 x 10e8 units/mg; Assay used to measure bioactivity: interferon was titrated with the use of the cytopathic effect inhibition assay as described [Rubinstein, S., Familletti, P.C., and Pestka, S. (1981'Convenient Assay for Interferons,' J. Virol. 37, 755-758; Familletti, P.C., Rubinstein, S., and Pestka, S. (1981)'A Convenient and Rapid Cytopathic Effect Inhibition Assay for Interferon,' in Methods in Enzymology, Vol. 78 (S. Pestka, ed.), Academic Press, New York, 387-394 ]. In this antiviral assay for interferon about 1 unit/mL of interferon is the quantity necessary to produce 50% cytopathic effect. The units are determined with respect to the international reference standard for human interferon-alphaA (Hu-IFN-α? provided by the National Institutes of Health [see Pestka, S. (1986)'Interferon Standards and General Abbreviations,' in Methods in Enzymology Vol. 119 (S. Pestka, ed.), Academic Press, New York, 14-23 ]. The activity was determined with bovine MDBK cells challenged with vesicular stomatitis virus (VSV).
Produkttyp Protein
Konjugat Unconjugated
Spezies Human
Rekombinant Recombinant
Inhalt und Lagerung -80°C
Aktivität Specific activity = 4.0x10e8 units/mg; Assay used to measure bioactivity: interferon was titrated with the use of the cytopathic effect inhibition assay as described [Rubinstein, S., Familletti, P.C., and Pestka, S. (1981 Convenient Assay for Interferons, J. Virol. 37, 755-758; Familletti, P.C., Rubinstein, S., and Pestka, S. (1981) A Convenient and Rapid Cytopathic Effect Inhibition Assay for Interferon, in Methods in Enzymology, Vol. 78 (S. Pestka, ed.), Academic Press, New York, 387-394]. In this antiviral assay for interferon about 1 unit/mL of interferon is the quantity necessary to produce 50% cytopathic effect. The units are determined with respect to the international reference standard for human interferon-alphaA (Hu-IFN-α? provided by the National Institutes of Health [see Pestka, S. (1986) Interferon Standards and General Abbreviations, in Methods in Enzymology Vol. 119 (S. Pestka, ed.), Academic Press, New York, 14-23]. The activity was determined with bovine MDBK cells challenged with vesicular stomatitis virus (VSV).
Versandbedingung Dry Ice
Expressionssystem E. coli
Proteinfamilie Cytokines & Receptors
Proteinform Recombinant, Ligand
Form Liquid
Protein-Subtyp Interferons
Forschungskategorie Immunology, Virology, Oncology, Signal Transduction
Produktlinie Gibco
Reinheits- oder Qualitätsgrad >95% by SDS-PAGE
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