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Invitrogen™ Human IL-4 Recombinant Protein

Artikelnummer. 17104273
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Menge:
5 μg
50 μg
Packungsgröße:
5 Mikrogramm
50 Mikrogramm
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17104273 5 μg 5 Mikrogramm
17114273 50 μg 50 Mikrogramm
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Artikelnummer. 17104273 Lieferant Invitrogen™ Lieferanten-Nr. A42602

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Recombinant Protein

Reconstitution: Dissolve the protein in sterile double distilled water to a concentration of 0.2 mg/mL or lower. It is recommended that the protein be aliquoted and be used as soon as possible. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles.

Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4.
TRUSTED_SUSTAINABILITY

Spezifikation

Zugriffsnummer P05112
Zur Verwendung mit (Anwendung) Control, Bioactivity, Immunohistochemistry, Western Blot
Zusammensetzung PBS with 5% mannitol, 5% trehalose, 0.01% Tween 80 and no preservative; pH 7.4
Gen-ID (Entrez) 3565
Molekulargewicht 15 kDa
Name Human IL-4
pH-Bereich 7.4
Reinigungsverfahren Purified
Menge 5 μg
Quelle E. coli
Lagerungsbedingungen -20°C or -80°C if preferred
Kennzeichnung RUO
Gen-Alias B cell growth factor 1; B_cell stimulatory factor 1; B-cell growth factor 1; B-cell IgG differentiation factor; B-cell stimulatory factor 1; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; cytokine; H-IL-4; IGG1 induction factor; IL2; IL4; Il-4; Il4e12; ILN; Interleukin; interleukin 4; interleukin 4 variant 2; interleukin 4 variant IL-4delta2; interleukin 4 variant IL-4delta3; interleukin 4 variant IL-4int2A; interleukin 4 variant IL-4int3A; interleukin 4 variant IL-4int3B; Interleukin4; interleukin-4; interleukin-4 precursor; lymphocyte stimulatory factor 1; MGC79402; M-IL-4; Pitrakinra
Gebräuchliche Bezeichnung IL-4
Gensymbol Il4
Biologische Aktivität Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 0.05-0.25 ng/mL
Produkttyp Protein
Konjugat Unconjugated
Spezies Human
Rekombinant Recombinant
Proteinmarkierung Untagged
Sequenz Human IL-4 isoform 1, amino acids His25-Ser153 (Accession # P05112-1) with an N-terminal Met
Inhalt und Lagerung Includes 1 vial of lyophilized protein. Store at -20 °C.
Aktivität Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 0.05-0.25 ng/mL.
Expressionssystem E. coli
Proteinfamilie Cytokines & Receptors
Proteinform Full Length, Recombinant
Form Lyophilized
Protein-Subtyp Interleukins
Forschungskategorie Immunology, Signal Transduction
Reinheits- oder Qualitätsgrad ≥95 % as determined by SDS-PAGE. ≥95 % as determined by SEC-HPLC.
Protein interleukin 4
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