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ACROBiosystems Human Leptin R / CD295 Protein, Fc Tag

Marke:  ACROBiosystems LER-H5252-100UG

Weitere Details : Netto-Gewicht : 0.00001kg

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Artikelnummer. 15897237

  • 330.73 € / 100 Mikrogramm
Verfügbar ab: 23-12-2022
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Beschreibung

Beschreibung

Leptin receptor (LEPR) is also known as LEP-R, cluster of differentiation 295 (CD295), OB-R and B219, is a single-transmembrane-domain receptor of the gp130 family of cytokine receptors. Leptin receptor exists as homodimer and binds Leptin with high affinity, thus mediates the biological function of the adipocyte-specific hormone Leptin. LEPR is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this protein have been associated with obesity and pituitary dysfunction. Interaction of leptin and leptin receptor is crucial for body weight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure. Meanwhile, research data supports a leptin receptor activation model based on ligand-induced conformational changes.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 119.6 kDa. The protein migrates as 150-165 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

NP_002294.2
119.6 kDa
100 µg
Phe 22 - Asp 839
LEPR,CD295,DKFZp686B1731,OBR,Leptin receptor
Unconjugated
50 mM Tris, 100 mM Glycine, pH7.5
HEK293
Human
Powder
>90% as determined by SDS-PAGE
Human Leptin R, Fc Tag (LER-H5252) is expressed from human 293 cells (HEK293). It contains AA Phe 22 - Asp 839 (Accession # NP_002294.2).
-20°C
Leptin R
Fc Tag
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
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Sicherheitsdatenblatt (SDS)
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