missing translation for 'onlineSavingsMsg'
Learn More
Learn More
ACROBiosystems Human Leptin R / CD295 Protein, Fc Tag
Marke: ACROBiosystems LER-H5252-100UG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
Leptin receptor (LEPR) is also known as LEP-R, cluster of differentiation 295 (CD295), OB-R and B219, is a single-transmembrane-domain receptor of the gp130 family of cytokine receptors. Leptin receptor exists as homodimer and binds Leptin with high affinity, thus mediates the biological function of the adipocyte-specific hormone Leptin. LEPR is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this protein have been associated with obesity and pituitary dysfunction. Interaction of leptin and leptin receptor is crucial for body weight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure. Meanwhile, research data supports a leptin receptor activation model based on ligand-induced conformational changes.
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 119.6 kDa. The protein migrates as 150-165 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| NP_002294.2 | |
| 100 μg | |
| Phe 22 - Asp 839 | |
| LEPR,CD295,DKFZp686B1731,OBR,Leptin receptor | |
| Unconjugated | |
| Fc Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >90% as determined by SDS-PAGE |
| 119.6 kDa | |
| Human Leptin R, Fc Tag (LER-H5252) is expressed from human 293 cells (HEK293). It contains AA Phe 22 - Asp 839 (Accession # NP_002294.2). | |
| -20°C | |
| Leptin R | |
| Human | |
| 50 mM Tris, 100 mM Glycine, pH7.5 | |
| HEK293 | |
| Bio-Markers and CD Antigens |