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Gibco™ Human LIF, Animal-Free Recombinant Protein, PeproTech®
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Menge:
1 mg
100 μg
25 μg
500 μg
Packungsgröße:
1 Milligramm
100 Mikrogramm
25 Mikrogramm
500 Mikrogramm
Beschreibung
Recombinant Human LIF is a 19.7 kDa protein containing 180 amino acid residues, including three disulfide bonds. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Leukemia inhibitory factor (LIF) is a 20 kDa protein that belongs to the IL-6 receptor family. It binds to a heterodimeric membrane receptor made up of a LIF-specific subunit, gp190 or LIFR, and the subunit gp130, which is shared with the other members of the IL-6 family. LIF expression has been observed in various tissues including thymus, lung, and neuronal tissue. LIF can be up-regulated by pro-inflammatory cytokines such as TNFα and IL-17, and elevated levels of LIF have been found in cases of rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis. LIF displays diverse biological effects, but is best known for its ability to inhibit the differentiation of embryonic stem cells in mice and contribute to stem cell self-renewal.Human and mouse LIF share 79% sequence homology and exhibit cross-species activity. However, LIF inhibition of stem cell differentiation appears to be mouse-specific.
Spezifikation
Spezifikation
| Zugriffsnummer | P15018 |
| Zur Verwendung mit (Anwendung) | Functional Assay |
| Zusammensetzung | protein with no preservative |
| Gen-ID (Entrez) | 3976 |
| Molekulargewicht | 19.6 kDa |
| Name | Human LIF, Animal-Free |
| Menge | 100 μg |
| Quelle | E. coli |
| Kennzeichnung | RUO |
| Endotoxin-Konzentration | <0.1 EU/ μg |
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