Invitrogen™ LOX-1/OLR Human ELISA Kit

Beschreibung

The Human LOX-1 (OLR) ELISA quantitates Hu LOX-1 in human serum, plasma, or cell culture medium. The assay will exclusively recognize both natural and recombinant Hu LOX-1. Principle of the method The Human LOX-1 solid-phase sandwich ELISA (enzyme-linked immunosorbent assay) is designed to measure the amount of the target bound between a matched antibody pair. A target-specific antibody has been pre-coated in the wells of the supplied microplate. Samples, standards, or controls are then added into these wells and bind to the immobilized (capture) antibody. The sandwich is formed by the addition of the second (detector) antibody, a substrate solution is added that reacts with the enzyme-antibody-target complex to produce measurable signal. The intensity of this signal is directly proportional to the concentration of target present in the original specimen. Rigorous validation Each manufactured lot of this ELISA kit is quality tested for criteria such as sensitivity, specificity, precision, and lot-to-lot consistency. See manual for more information on validation.

Dieses Gen kodiert einen Lipoprotein-Rezeptor mit niedriger Dichte, der zur C-Typ-Lektin-Superfamilie gehört. Dieses Gen wird über den zyklischen AMP-Signalweg reguliert. Das kodierte Protein bindet, verinnerlicht und degradiert oxidiertes Lipoprotein niedriger Dichte. Dieses Protein kann an der Regulation der Fas-induzierten Apoptose beteiligt sein. Dieses Protein kann eine Rolle als Scavenger-Rezeptor spielen. Mutationen dieses Gens wurden mit Atherosklerose, dem Risiko eines Myokardinfarkts, in Verbindung gebracht und können das Risiko einer Alzheimer-Krankheit verändern. Alternatives Spleißen führt zu mehreren Transkriptvarianten.