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ACROBiosystems Human Siglec-3 / CD33 Protein, Llama IgG2b Fc Tag, low endotoxin
low endotoxin
423.38 € - 2818.49 €
Spezifikation
| Zugriffsnummer | AAH28152.1 |
|---|---|
| Molekulargewicht | 54.6 kDa |
| Quelle | Human Siglec-3, Llama IgG2b Fc Tag, low endotoxin (CD3-H5259) is expressed from human 293 cells (HEK293). It contains AA Asp 18 - His 259 (Accession # AAH28152.1). |
| Immunogen | Asp 18 - His 259 |
| Lagerungsbedingungen | -20°C |
| Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
|---|---|---|---|---|---|---|---|---|---|
| Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
|
15806177
|
ACROBiosystems
CD3-H5259-1MG |
1 mg |
2818.49 €
1 Milligramm |
Verfügbar ab: 30-04-2024 Loggen Sie sich ein, um den Lagerbestand zu sehen |
Bitte melden Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute! | ||||
|
15896167
|
ACROBiosystems
CD3-H5259-100UG |
100 μg |
423.38 €
100 Mikrogramm |
Verfügbar ab: 30-04-2024 Loggen Sie sich ein, um den Lagerbestand zu sehen |
Bitte melden Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute! | ||||
Beschreibung
Myeloid cell surface antigen CD33 is also known as SIGLEC3, Siglecs (sialic acid binding Iglike lectins) and GP67, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Human CD33 / Siglec-3 cDNA encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-terminal Ig-like V-type domain, one Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail. CD33 / Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells. In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia.
This protein carries a llama IgG2b Fc tag at the C-terminus. The protein has a calculated MW of 54.6 kDa. The protein migrates as 64-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| AAH28152.1 | |
| Human Siglec-3, Llama IgG2b Fc Tag, low endotoxin (CD3-H5259) is expressed from human 293 cells (HEK293). It contains AA Asp 18 - His 259 (Accession # AAH28152.1). | |
| -20°C | |
| Siglec-3 | |
| Human | |
| Tris with Glycine, Arginine and NaCl, pH7.5 | |
| HEK293 | |
| Bio-Markers and CD Antigens |
| 54.6 kDa | |
| Asp 18 - His 259 | |
| CD33,SIGLEC3,gp67 | |
| Unconjugated | |
| Llama IgG Fc Tag | |
| Less than 0.01 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |