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IL-12/IL-23 p40 Mouse anti-Human, Functional Grade, Clone: C8.6, eBioscience™

Mouse Monoclonal Antibody

Marke:  Affymetrix eBioscience 16-7129-85

Weitere Details : Netto-Gewicht : 0.01000kg

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Artikelnummer. 15258767

  • 270.00 € / 500 Mikrogramm

Verfügbar ab
21-05-2021

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Beschreibung

Beschreibung

Description: The C8.6 antibody reacts with the p40 subunit of human IL-12 p70 and human IL-23. IL-12 is a 70 kDa heterodimeric cytokine composed of two covalently linked chains, p40 and p35, and secreted primarily by activated monocytes, macrophages, and dendritic cells. IL-23 is a biologically-related, heterodimeric cytokine composed of disulfide-linked p40 and p19 subunits. Applications Reported: The C8.6 antibody has been reported for use ELISA, ELISPOTand neutralization. Applications Tested: The Functional Grade Purified C8.6 antibody has been tested by LAL assay to verify low endotoxin levels and has been tested for ELISA detection and in bioassay for neutralization of IL-12 p70 and IL-23 bioactivity. The C8.6 antibody at 60.0 ng/mL has been found to inhibit by 50% the biological effects of 1 ng/mL human IL-12 p70 (14-8129) or human IL-23 (14-8239), in corresponding bioassay. Detailed information and protocols about cytokine bioassays and in vitro cytokine neutralization using antibodies can be found in the BestProtocols™ section. Endotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay. Storage and handling: Use in a sterile environment. Filtration: 0.2 μm post-manufacturing filtered. Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC.

IL-12 is an interleukin produced by dendritic cells, neutrophils, macrophages and human lymphoblastoid cells as a result of antigenic stimulation. IL-12 is a heterodimeric cytokine encoded by IL-12A (p35) and IL-12B (p40). IL-23 is a heterodimeric cytokine that shares a subunit with IL-12 (IL-12B) along with an IL-23A (IL-23p19) subunit. Functionally, IL-12 increases the expression of vascular endothelial adhesion molecule-1 on the endothelium, directs leukocytes towards tumors and facilitates the ischemic-hemorrhagic necrosis of the tumor tissue. In comparison, IL-23 plays an important role in stimulating memory T-cells, and is required for the induction, expansion, maintece and downstream effector functions of Th17 cells, which play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines.
Spezifikation

Spezifikation

IL-12/IL-23 p40
Monoclonal
1 mg/mL
PBS with no preservative; pH 7.2
P29460
IL12B; Il12p40; interleukin 12B; RP23-388G23.1; Il-12b; Il-12p40; p40; IL-12 p40; IL-23 subunit p40; IL12P40
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
ELISA, Functional Assay, Neutralization
C8.6
Functional Grade
IL12B
Liquid
IL12B
IgG1, kappa
500 μg
4° C
Primary
3593
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.