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IQGAP3 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marke: Thermo Scientific PA556363
Weitere Details : Netto-Gewicht : 0.02000kg
Beschreibung
Immunogen sequence: SALLLPAAGL DDVSLPVAPR YHLLLVAAKR QKAQVTGDPG AVLWLEEIRQ GVVRANQDTN TAQRMALGVA AINQAIKEGK AAQTERVL Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 93%.
IQGAP3 (IQ motif containing GTPase activating protein 3) is a 1,631 amino acid protein that acts as an effector of Cdc42 and Rac 1, linking their activation to the cytoskeleton during neuronal morphogenesis. A novel member of the IQGAP family, IQGAP3 is highly expressed in brain where it localizes to axons of hippocampal neurons. IQGAP3 contains one Ras-GAP domain, a CH (calponin-homology) domain, four IQ domains and is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson's disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.Spezifikation
IQGAP3 | |
Polyclonal | |
Unconjugated | |
IQGAP3 | |
AI593484; D030034H08; IQ motif containing GTPase activating protein 3; IQGA3; IQGAP3; MGC10170; Ras GTPase-activating-like protein IQGAP3 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
128239 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry | |
0.1 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q86VI3 | |
IQGAP3 | |
Recombinant protein corresponding to Human IQGAP3 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Research Use Only