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IRF4 Monoclonal Antibody (3E4), PE-Cyanine7, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

134.00 € - 330.00 €

Spezifikation

Antigen IRF4
Klon 3E4
Konzentration 0.2 mg/mL
Anwendungen Flow Cytometry
Klassifikation Monoclonal
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Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15508686
Unterlagen ansehen Aktionsdetails
Affymetrix eBioscience
25-9858-80
25 μg
134.00 €
25 Mikrogramm
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Verfügbar ab: 09-04-2024
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15518686
Unterlagen ansehen Aktionsdetails
Affymetrix eBioscience
25-9858-82
100 μg
330.00 €
100 Mikrogramm
Alternative Produkte anzeigen
Sparen Sie bis zu 
»
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Beschreibung

Beschreibung

Description: The monoclonal antibody 3E4 reacts with human and mouse interferon regulatory factor 4 (IRF4). IRF4 is a 52 kDa transcription factor with roles in B cell, T cell and macrophage function. In B cells, IRF4 is highly expressed in mature plasma cells and plays a crucial role in their differentiation. IRF4 has been shown to interact with PU.1 and control the transcription of many B cell-specific genes including Prdm1, which encodes Blimp1. In T cells, IRF4 has been implicated in regulatory T (Treg), Th2, Th9 and Th17 cell development and function. This transcription factor is upregulated upon T cell activation and is expressed in mature T cells. Studies have shown that IRF4 directly induces Blimp1 expression in Tregs, leading to IL-10 expression. IRF4 has also been demonstrated to be involved in macrophage polarization and regulation. Lastly, in addition to its roles in normal immune function, IRF4 expression has been reported to be upregulated in many blood-related cancers. Applications Reported: This 3E4 antibody has been reported for use in intracellular staining followed by flow cytometric analysis. Applications Tested: This 3E4 antibody has been tested by intracellular staining and flow cytometric analysis of stimulated normal human peripheral blood cells using the Foxp3/Transcription Factor Buffer Set (cat 00-5523) and protocol.

IRF4 Monoclonal antibody specifically detects IRF4 in Human, Mouse samples. It is validated for Flow Cytometry.
Spezifikation

Spezifikation

IRF4
0.2 mg/mL
Monoclonal
Liquid
RUO
PBS with 0.09% sodium azide; pH 7.2
AI385587; interferon regulatory factor 4; Irf4; IRF-4; LSIRF; Lymphocyte-specific interferon regulatory factor; multiple myeloma oncogene 1; MUM1; NF-EM5; PU.1 interaction partner; Sfpi1/PU.1 interaction partner; SHEP8; Spip; Transcriptional activator PIP
IRF4
Primary
4° C, store in dark, DO NOT FREEZE!
IRF4
3E4
Flow Cytometry
PE-Cyanine7
Rat
Human, Mouse
Q15306, Q64287
16364, 3662
IgG1 κ
Affinity chromatography
Antibody
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Produktzertifizierungen

For Research Use Only.