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IRF8 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marke:  Proteintech 24437-1-AP-20UL

Weitere Details : Netto-Gewicht : 0.00010kg

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Artikelnummer. 16882915

  • 112.71 € / 20 Mikroliter

Verfügbar ab
16-06-2021

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Beschreibung

Beschreibung

This antibody specifically recognizes the 48 kDa IRF8 protein.

IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.
Spezifikation

Spezifikation

IRF8
0.34 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q02556
H ICSBP, ICSBP, ICSBP1, interferon regulatory factor 8, IRF 8, IRF8
Rabbit
IgG
20 μL
-20°C
Primary
3394
Western Blot
Unconjugated
IRF8
Liquid
IRF8
IRF8 Fusion Protein Ag19909
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation