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Invitrogen™ Human MMP9, Recombinant Protein
Recombinant Protein
Marke: Invitrogen™ RP75654
Weitere Details : CAS : 69-74-9 Netto-Gewicht : 0.01000kg
Beschreibung
MMP9 (human) Recombinant Protein, RP-75654, from Invitrogen.
MMP9 (matrix metallopeptidase 9, GELB, CLG4B) is a matrix metalloproteinase, a family of zinc and calcium-dependent endopeptidases that degrade extracellular matrix proteins. MMP9 is secreted as a 92kDa zymogen and cleavage of pro-MMP9 results in the active enzyme with a molecular weight of 82kDa. MMP9 has a gelatin-binding domain consisting of three fibronectin type II units, a catalytic domain containing the zinc-binding site, a proline-rich type V collagen-homologous domain and a hemopexin-like domain. MMP9 is produced by monocytes, macrophages, neutrophils, keratinocytes, fibroblasts, osteoclasts and endothelial cells, and is involved in inflammatory responses, tissue remodeling, wound healing, tumor growth and metastasis. MMP9 is supplied by bone marrow-derived cells and contributes to skin carcinogenesis. Further, MMP9 degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. Studies have shown that elevated MMP9 is associated with progression of idiopathic atrial fibrillation and aortic aneurysm. This product contains purified recombinant human MMP-9 protein with an N-terminal hexahistidine tag. This product may be used as a positive control in many immunological assays. This protein has a molecular weight of ∽42.03 kDa.Spezifikation
P14780 | |
Control, Western Blot | |
4318 | |
8 | |
E. Coli | |
RUO | |
MMP9 | |
Unconjugated | |
E. coli | |
Liquid | |
purified |
0.70mg/mL | |
tris HCl with 50% glycerol and no preservative; pH 8 | |
Human MMP9 | |
100μg | |
-20°C, Avoid Freeze/Thaw Cycles | |
Human MMP9 | |
Human | |
Hu | |
Recombinant | |
Recombinant |