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Beschreibung
Transcriptional control is in part regulated by interactions between DNA-bound transcription factors, such as Egr-1/NGFI-A, and coregulatory proteins, such as NAB (for NGFI-A-binding proteins). The evolutionarily conserved NAB proteins, NAB1 and NAB2, are corepressors of EGF-1/NGFI-A. Both NAB1 and NAB2 contain an amino terminal NAB conserved domain 1 (NCB1), which is required for binding NGFI-A, and a carboxy terminal NCD2 domain, which is responsible for the repressor function of NAB proteins. NAB2 is principally localized in the nucleus and may play a role in the downregulation of NGFI-A activity as well as in controlling fundamental processes such as cell division, differentiation and apoptosis. NAB2 has a predicted molecular mass of 56 kDa and localizes to chromosome 12q13.3-14.1, a region that is rearranged in several solid tumors, lipomas and liposarcomas.
Spezifikation
Spezifikation
| Antigen | NAB2 |
| Anwendungen | Immunohistochemistry (Paraffin), Immunoprecipitation, Immunofluorescence, Immunocytochemistry, Western Blot |
| Klassifikation | Polyclonal |
| Konzentration | 0.16 mg/mL |
| Konjugat | Unconjugated |
| Zusammensetzung | PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 |
| Gen | NAB2 |
| Gen-Zugriffsnummer | Q15742, Q61127 |
| Gen-Alias | EGR 1 binding protein 2, MADER, NAB2, NGFI A binding protein 2, Protein MADER |
| Gensymbole | Nab2 |
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Name des Produkts
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