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Invitrogen™ NDFIP2 Polyclonal Antibody
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Artikelnummer. 16657364
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Menge:
100 μL
Packungsgröße:
100 Mikroliter
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16657364 100 μL 100 Mikroliter
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Artikelnummer. 16657364 Lieferant Invitrogen™ Lieferanten-Nr. PA5100882

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total NDFIP2.

Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (PubMed:26363003). May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen NDFIP2
Anwendungen Immunohistochemistry (Paraffin), Western Blot
Klassifikation Polyclonal
Konzentration 1 mg/mL
Konjugat Unconjugated
Zusammensetzung PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gen NDFIP2
Gen-Zugriffsnummer Q91ZP6, Q9NV92
Gen-Alias 0710001O20Rik; 2810436B12Rik; 9130207N19Rik; KIAA1165; MAPK-activating protein PM04 PM05 PM06 PM07; mKIAA1165; N4wbp5a; NDFIP2; Nedd4 family interacting protein 2; NEDD4 family-interacting protein 2; NEDD4 WW domain-binding protein 5A; NF-kappa-B-activating protein 413; putative MAPK-activating protein PM04/PM05/PM06/PM07; Putative NF-kappa-B-activating protein 413; Unknown (protein for IMAGE:7958216); wu:fa92h03; wu:fk31f07; zgc:63948
Gensymbole NDFIP2
Wirtsspezies Rabbit
Immunogen A synthesized peptide derived from human NDFIP2(Accession Q9NV92), corresponding to amino acid residues G61-E111.
Reinigungsverfahren Affinity Chromatography
Menge 100 μL
Regulatorischer Status RUO
Primär oder sekundär Primary
Gen-ID (Entrez) 54602, 76273
Zielspezies Human, Mouse
Inhalt und Lagerung -20°C
Produkttyp Antibody
Form Liquid
Isotype IgG
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