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Invitrogen™ Human NUAK2, GST Tag Recombinant Protein
NUAK2 or SNF1/AMP kinase-related kinase (SNARK) is a member of the NUAK family of SNF1-like kinase 2. Recombinant full-length human NUAK2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Marke: Invitrogen™ PV6376
Weitere Details : Netto-Gewicht : 0.01000kg
Beschreibung
NUAK2 is activated by muscle contraction and is a unique mediator of contraction-stimulated glucose transport in skeletal muscle (1). NUAK2 is involved in cellular stress responses linked to obesity and type 2 diabetes. NUAK2 shows kinase activity against a synthetic test peptide and the activity in keratinocytes is increased by AMP and 5-amino-4-imidazolecarboxamide riboside, implying that AMPK kinase-dependent pathway can activate NAUK2. Glucose deprivation also increases NAUK2 activity in baby hamster kidney fibroblasts.
- Validated in LanthaScreen™ Kinase Binding Assay
- Protocols available for simple use and optimized performance
- Multiple pack sizes available for convenient use
Spezifikation
| Kinase Assay | |
| 10μg | |
| Human | |
| GST Tag | |
| Biochemical binding/kinetic | |
| NUAK2 | |
| Kinases & Inhibitors |
| 96.3 kDa | |
| SNARK, FLJ90349, DKFZP434J037, DKFZp686F01113 | |
| Recombinant | |
| Storage Buffer: 50 mM Tris-HCl pH 7.5, 150 mM NaCl, 0.25 mM DTT, 10 mM glutathione, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws. |
|
| Serine/Threonine Kinase | |
| Baculovirus | |
| Recombinant, Full Length |