OGDH Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Beschreibung

This antibody is immunized with the C-terminal and can recognize the isoform 1 and 2 with the MW of 116 kDa.

This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia.