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PI4K2A Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marke:  Proteintech 15318-1-AP-150UL

Weitere Details : Netto-Gewicht : 0.00010kg

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Artikelnummer. 16884444

  • 399.00 € / 150 Mikroliter
Verfügbar ab: 04-04-2024
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Beschreibung

Beschreibung

Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs. PI4K II is activated by detergent and inhibited by adenosine. Overexpression of PI4KII in COS-7 cells increases synthesis of PtdIns4P. Some cells overexpressing PI4KII have scattered or no perinuclear Golgi. Knockdown of PI4KII by RNA interference (RNAi) does not disrupt the Golgi, and some cells show expanded Golgi. RNAi reduces the Golgi level of PtdIns4P and blocks the association between AP1 and the trans-Golgi network. PI4KII RNAi had little effect on intra-Golgi trafficking, but it inhibited export to plasma membrane export by 35%. It has been proposed that PI4KII generates PtdIns4P-rich domains within the Golgi that specify docking of the AP1 coat machinery.
Spezifikation

Spezifikation

PI4K2A
Polyclonal
Unconjugated
PI4K2A
PI 4-kinase II alpha, PI4K2A, PI4KII, PIK42A, RP11 548K23.6
Rabbit
Antigen Affinity Chromatography
RUO
114554, 55361, 84095
-20°C
Liquid
Western Blot
0.13 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q2TBE6, Q99M64, Q9BTU6
PI4K2A
PI4K2A Fusion Protein Ag7564
150 μL
Primary
Human, Mouse, Rat
Antibody
IgG
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote