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Thermo Scientific™ MM(PEG)24 Methyl-PEG-Maleimide Reagent

Product Code. 11831325 Shop All Thermo Scientific Products
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Quantity:
100 mg
Unit Size:
100mg
Product Code. Quantity unitSize
11831325 100 mg 100mg
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Product Code. 11831325

Brand: Thermo Scientific™ 22713

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Description

Pegylate sulfhydryls (-SH groups) on proteins (cysteine residues) or assay surfaces using MS(PEG); sulfhydryl-reactive (maleimide), PEG compounds (12 and 24 EG units).

Thermo Scientific™ Pierce MM(PEG)12 is a methyl-terminated, polyethylene glycol compound (3 times 12 PEG units) activated with a maleimide group for covalent pegylation of sulfhydryls on proteins (e.g., cysteines) or assay surfaces.

MM(PEG)n is the abbreviation for a set of compounds having polyethylene glycol (PEG) spacers with methyl (—CH3) and sulfhydryl-reactive maleimide groups at opposite ends. The unbranched, hydrophilic, discrete-length molecules have the form Methyl-PEGn-Maleimide, where the subscript “n” denotes 12 or 24 ethylene glycol units. The maleimide is spontaneously reactive with sulfhydryl (—SH) groups, providing for efficient PEGylation of proteins, peptides and other cysteine- or thiol-containing molecules.

Highlights:

  • Maleimide-activated for efficient PEGylation of sulfhydryl groups at pH 6.5-7.5; reaction of maleimide group results in formation of stable, irreversible thioether bonds
  • Fully characterized PEGylation reagents with defined PEG chain lengths; molecules of discrete molecular weight for consistency of performance in protein-modification applications
  • Provided with either 12 or 24 ethylene glycol units, enabling modification procedures to be optimized for a specific application while retaining all the benefits associated with protein PEGylation
  • PEG spacer provides unique advantages, including increased stability, reduced tendency toward aggregation and reduced immunogenicity
  • Easy-to-follow instructions increase the likelihood of a successful outcome
TRUSTED_SUSTAINABILITY

Specifications

Chemical Reactivity Thiol
Description Pierce MM(PEG)24
Content And Storage Upon receipt store desiccated at 4°C. Product is shipped at ambient temperature.
Label Type Polyethylene Glycol (PEG), Blocking Groups
Reactive Moiety Maleimide
Spacer 24 ethylene glycol units
Form Powder
Quantity 100 mg
Solubility Water
Product Type Maleimide Reagent

For Research Use Only. Not for use in diagnostic procedures.

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