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Human PIK3CB/PIK3R1 (p110 beta/p85 alpha), His Tag Recombinant Protein
Human PIK3CB/PIK3R1 (p110 beta/p85 alpha), His Tag Recombinant Protein
Marke: Thermo Scientific PV6454
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
PIK3CB/PIK3R1 (p110β/p85α) is a phosphoinositide-3-kinase (PI3K) comprised of a catalytic subunit, p110β, and a regulatory subunit, p85α, encoded by the PIK3CB and PIK3R1 genes respectively. As with other members of the PI3K family, p110β has important regulatory roles in cellular processes including cell survival, proliferation, and differentiation. It affects growth factor signaling and survival by phosphorylating inositol lipids. PTEN-deficient cancer cells have been observed to depend on p110β signaling.PIK3CB/PIK3R1 (p110β/p85α) Recombinant Human Protein is:
Related assay platforms:
LanthaScreen™ Kinase Binding Assay
Adapta™ Kinase Activity Assay
Spezifikation
| NP_006210.1, NP_852664.1 | |
| PIK3R1, PIK3CB | |
| 20 μg | |
| PI3 Kinase | |
| Recombinant | |
| Storage buffer: 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol. Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws. |
|
| Baculovirus | |
| Full Length, Recombinant, Active | |
| Signal Transduction, Drug Development, Oncology |
| Kinase Assay | |
| 123.7 kDa, 84.7 kDa | |
| phosphatidylinositol-4, 5-bisphosphate 3-kinase, p110 beta/p85 alpha, p110β/p85α | |
| Human | |
| His Tag | |
| Dry Ice | |
| Kinases & Inhibitors | |
| Liquid |