PIKFYVE Polyclonal Antibody, Invitrogen™

Beschreibung

Immunogen sequence: NVELDNVNFH IKKPSKYPHV PPHPADQKEY LISDTGGQQL SISDAFIKES LFNRRVEEKS KELPFTPLGW HHNNLELLRE ENGEKQA Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.

PIKFYVE belongs to a large family of lipid kinases that alter the phosphorylation status of intracellular phosphatidylinositol. The content of phosphatidylinositol 3,5-bisphosphateP2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. PIKFYVE is the PtdIns(3,5)P2-producing component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PIKFYVE activator VAC14 and the PtdIns(3,5)P2 phosphatase FIG4. In addition to its phosphoinositide 5-kinase activity, PIKFYVE also has protein kinase activity. For a review, see Shisheva.