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R&D Systems™ b-AP15/VLX1500
Specifically inhibits the 19S regulatory particle-associated deubiquitinases USP14 and UCHL5, resulting in the accumulation of intracellular polyubiquitin
N.V.
Beschreibung
b-AP15 has been shown to inhibit tumor progression in at least four solid tumor models, and also inhibits organ infiltration in an acute myeloid leukemia (AML) model.
- Potent, reversible, cell-permeable inhibitor
- Purity >97% by HPLC
- Decreases HCT-116 cell viability at 72 hours (EC50 = 0.4μM)