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Tocris Bioscience™ RQ 00203078

Potent and selective TRPM8 antagonist; orally active

N.V.

Spezifikation

Produkttyp RQ 00203078
Beschreibung RQ 00203078
Molekulargewicht 554.85
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Beschreibung

Beschreibung

Potent TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively). Exhibits >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1. Reduces HSC3 and HSC4 oral squamous carcinoma cell migration and invasion in vitro. Also attenuates icilin -induced wet dog shakes in rats. Orally active.
Spezifikation

Spezifikation

RQ 00203078
RQ 00203078
554.85
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Dokumentation

Dokumentation

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For Research Use Only