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STEMCELL Technologies RS-1

Product Code. 17170322
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Quantity:
10 mg
25 mg
Unit Size:
10mg
25mg
Product Code. Quantity unitSize
17170322 10 mg 10mg
17180322 25 mg 25mg
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Product Code. 17170322

Brand: STEMCELL Technologies 74092

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Description

HDR pathway enhancer; Enhances RAD51

  • RS-1 is an enhancer of RAD51, an enzyme that assists in the homology-directed repair (HDR) pathway of DNA double-strand breaks, and is reported to function by stabilizing the active form of RAD51 and by enhancing recombinogenic activity of the enzyme (Jayathilaka et al.) Via this mechanism, RS-1 can stimulate HDR, thereby enhancing precise HDR-dependent CRISPR-Cas9 genome editing in some cell lines (Pinder et al.; Song et al.)
  • Promotes HDR, which is reported to enhance knock-in efficiency of CRISPR-Cas9 genome editing (Pinder et al.; Song et al.; however, these effects are cell type-specific and context-dependent (Xie et al.; Zhang et al.)
  • Stimulates the DNA-binding activity of RAD51 to promote cancer cell death and induce anti-tumor responses in a mouse xenograft tumor model (Mason et al.)

Specifications

CAS 312756-74-4
Quantity 10 mg
Molecular Formula C20H16Br2N2O3S
Purity ≥95%
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