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SCIO 469 hydrochloride, Tocris Bioscience™

Selective p38 MAPK inhibitor

Marke:  Tocris (Bio-Techne) 352850

Weitere Details : Netto-Gewicht : 0.01000kg

Menge. 50mg

 Weitere Artikel aus diesem Sortiment

Artikelnummer. 13413144

  • 1078.98 € / 50 Milligramm

Voraussichtlicher Liefertermin 29-10-2019

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Beschreibung

Beschreibung

Selective, ATP-competitive p38 inhibitor (IC50 = 9 nM for p38α in vitro). Displays approximately 10-fold selectivity for p38α over p38β and 2000-fold selectivity for p38α over 20 other kinases. Reduces p38α phosphorylation in multiple myeloma cells in vitro and in vivo; activity results in decreased tumor burden and angiogenesis in murine models of multiple myeloma. Also enhances bortezomib-induced cytotoxicity against multiple myeloma cells.
Spezifikation

Chemische Identifikatoren

309913-83-5
513.01
talmapimod, scio-469, scios 469, scio 469, unii-b1e00kq6nt, b1e00kq6nt, scio 469 hydrochloride, 2-6-chloro-5-2r,5s-4-4-fluorobenzyl-2,5-dimethylpiperazin-1-yl carbonyl-1-methyl-1h-indol-3-yl-n,n-dimethyl-2-oxoacetamide, talmapimod usan, talmapimod usan:inn
2-[6-chloro-5-[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethylpiperazine-1-carbonyl]-1-methylindol-3-yl]-N,N-dimethyl-2-oxoacetamide
C27H30ClFN4O3
ZMELOYOKMZBMRB-DLBZAZTESA-N
9871074
CC1CN(C(CN1C(=O)C2=C(C=C3C(=C2)C(=CN3C)C(=O)C(=O)N(C)C)Cl)C)CC4=CC=C(C=C4)F

Spezifikation

50mg
309913-83-5
talmapimod, scio-469, scios 469, scio 469, unii-b1e00kq6nt, b1e00kq6nt, scio 469 hydrochloride, 2-6-chloro-5-2r,5s-4-4-fluorobenzyl-2,5-dimethylpiperazin-1-yl carbonyl-1-methyl-1h-indol-3-yl-n,n-dimethyl-2-oxoacetamide, talmapimod usan, talmapimod usan:inn
CC1CN(C(CN1C(=O)C2=C(C=C3C(=C2)C(=CN3C)C(=O)C(=O)N(C)C)Cl)C)CC4=CC=C(C=C4)F
513.01
549.46
SCIO 469 hydrochloride
C27H30ClFN4O3
ZMELOYOKMZBMRB-DLBZAZTESA-N
2-[6-chloro-5-[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethylpiperazine-1-carbonyl]-1-methylindol-3-yl]-N,N-dimethyl-2-oxoacetamide
9871074
>98%
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