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SCUBE3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marke:  Proteintech 16773-1-AP-150UL

Weitere Details : Netto-Gewicht : 0.00010kg

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Artikelnummer. 16886504

  • 329.85 € / 150 Mikroliter

Verfügbar ab
17-06-2021

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Beschreibung

Beschreibung

SCUBE3 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and is highly expressed in primary osteoblasts and bones, and to a lesser extent in heart. Other studies have shown that overexpression of SCUBE3 in mice induced cardiac hypertrophy, suggesting that it may also play a role in the regulation of cardiac growth. SCUBE3 has been shown to be an endogenous TGF-Beta receptor ligand and is thought to promote lung cancer cell mobility and invasiveness. In lung cancer cells, the secreted SCUBE3 protein was cleaved by MMP2 and MMP9, allowing the activation of the TGF-Beta receptor, the increase of Smad2/3 transcriptional activity and the upregulation of expression of proteins such as TGF-Beta1, VEGF, Snail, and Slug.
Spezifikation

Spezifikation

SCUBE3
0.13 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q66PY1, Q8IX30
CEGF3, SCUBE3
Rabbit
IgG
150 μL
-20°C
Primary
222663, 268935, 294297
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
SCUBE3
Liquid
SCUBE3
SCUBE3 Fusion Protein Ag10085
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation