SYNPO2L Polyclonal Antibody, Invitrogen™

Beschreibung

Immunogen sequence: PAEALLLPHG PLRPGPHLIP MVGPVPHPVA EDLTTTYTQK AKQAKLQRAE SLQEKSIKEA KTKCRTIASL LTA Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 99%.

SYNPO2L was initially identified as a novel heart-enriched gene that encodes a cytoskeletal protein highly expressed in the Z-disc of heart and skeletal muscle, associates with actin and interacts with a-actinin. It is a member of the synaptopodin family, sharing greatest homology with Synaptopodin 2. Recent studies have shown that SYNPO2L, while primarily localized to the sarcomere, can also translocate to the nucleus. A knockdown of SYNPO2L in zebrafish resulted in aberrant cardiac and skeletal muscle development and function, suggesting that it is a critical component of the sarcomere and plays an important role in muscle development.