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Tocris Bioscience™ Targapremir 210

Inhibits formation of miR-210

Marke:  Tocris Bioscience™ 6586/5

Weitere Details : Netto-Gewicht : 0.00970kg

Artikelnummer. 18716566

  • 356.36 € / 5 Milligramm
Verfügbar ab: 22-07-2024
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Beschreibung

Beschreibung

Targapremir 210 inhibits formation of mature miR-210 (IC50 = 200 nM) by binding to Dicer binding site of the miR-210 hairpin precursor (Kd = 200 nM) and inhibits Dicer processing of the miRNA. Decreases levels of miR-210 and HIF-1α mRNA, and induces apoptosis in MDA-MB-231 cells cultured under hypoxic conditions. Reduces tumor expression of HIF-1α mRNA and miR-210, and tumor growth in a triple negative breast cancer mouse model.
Spezifikation

Spezifikation

N-(3-Azidopropyl)-4-[3-[6-(4-methyl-1-piperazinyl)[2,6'-bi-1H-benzimidazol]-2'-yl]phenoxy]butanamide
5 mg
98%
1049722-30-6
C32H36N10O2
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