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Invitrogen™ TGM2 Polyclonal Antibody
Beschreibung
TGM2 Polyclonal Antibody for Western Blot, ICC/IF, IHC (P), ELISA
Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.
Spezifikation
Spezifikation
| Antigen | TGM2 |
| Anwendungen | ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry |
| Klassifikation | Polyclonal |
| Konzentration | 3 mg/mL |
| Konjugat | Unconjugated |
| Zusammensetzung | PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4 |
| Gen | TGM2 |
| Gen-Zugriffsnummer | P21980 |
| Gen-Alias | C polypeptide; C polypeptide, protein-glutamine-gamma-glutamyltransferase; G alpha h; G[a]h; G-ALPHA-h; GNAH; Protein-glutamine gamma-glutamyltransferase 2; protein-glutamine-gamma-glutamyltransferase; RP5-1054A22.2; TG C; TG(C); TG2; TGase C; TGase H; TGase2; TGase-2; TGase-H; TgaseII; TGC; TGM2; Tissue transglutaminase; Tissue type transglutaminase; tissue-type transglutaminase; transglutaminase; transglutaminase 2; transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); Transglutaminase 2 C polypeptide; transglutaminase 2, C polypeptide; transglutaminase C; Transglutaminase H; transglutaminase-2; tTG; tTGas |
| Gensymbole | TGM2 |
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