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Invitrogen™ Human IL-1 beta Recombinant Protein

Recombinant Protein

Marke:  Invitrogen™ RP75584

Weitere Details : CAS : 69-74-9 Netto-Gewicht : 0.01000kg

Artikelnummer. 11538911

  • 242.00 € / 10 Mikrogramm
Verfügbar ab: 25-04-2024
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Beschreibung

Beschreibung

IL-1 beta (human) Recombinant Protein, RP-75584, from Invitrogen.

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value. RP-75584 contains purified recombinant human IL-1 beta protein with an N-terminal hexahistidine tag. RP-75584 may be used as a positive control in many immunological assays. This protein has a molecular weight of ∽21.88 kDa.
Spezifikation

Spezifikation

P01584
Control, Western Blot
3553
Human IL-1 beta
E. coli
RUO
IL1B
Unconjugated
E. coli
Liquid
purified
0.05mg/mL
Laemmli with no preservative
∽21.88
10μg
-20°C
Human IL-1 beta
Human
Hu
Recombinant
Recombinant
Produktvorschläge

Produktvorschläge

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Dokumentation

Dokumentation

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Sonderangebote

Sonderangebote