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Invitrogen™ Human SCF Recombinant Protein
Recombinant Protein
Marke: Invitrogen™ RP8631
Weitere Details : Netto-Gewicht : 0.01000kg
Beschreibung
Stem Cell Factor (human) Recombinant Protein, RP-8631, from Invitrogen.
Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist. Recombinant human SCF is a non-glycosylated protein, containing 165 amino acids, with a molecular weight of 18.4 kDa Purity is typically greater than 98% and endotoxin level less than 1 EU/ug. The expected biological activity (ED50) is determined by the dose-dependent stimulation of Human TF-1 cells and is typically 1-5ng/mL. The specific activity of this protein is 1x10^6 units/mg. Reconstitute using sterile water at 0.1mg/mL and centrifuge prior to opening vial. Gently pipet solution down the sides of the vial. DO NOT VORTEX sample. Store reconstituted material at -20°C and add 0.1% BSA for additional stability. Amino acid sequence: MEGICRNRVT NNVKDVTKLV ANLPKDYMIT LKYVPGMDVL PSHCWISEMV VQLSDSLTDL LDKFSNISEG LSNYSIIDKL VNIVDDLVEC VKENSSKDLK KSFKSPEPRL FTPEEFFRIF NRSIDAFKDF VVASETSDCV VSSTLSPEKD SRVSVTKPFM LPPVA.Spezifikation
P21583 | |
Control | |
4254 | |
Human Stem Cell Factor (SCF) | |
10μg | |
-20°C, Avoid Freeze/Thaw Cycles | |
H-SCF | |
KITLG | |
Unconjugated | |
E. coli | |
Lyophilized | |
purified |
0.1mg/mL | |
10mM sodium phosphate with 50mM NaCl and no preservative; pH 7.5 | |
∽18.4 | |
7.5 | |
E. coli | |
RUO | |
Human Stem Cell Factor (SCF) | |
Human | |
Hu | |
Recombinant | |
Recombinant |
in vitro research only.