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Tocris Bioscience™ Topiramate

GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV

Marke:  Tocris Bioscience™ 362010

Weitere Details : Netto-Gewicht : 0.01000kg

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Artikelnummer. 13413304

  • 139.05 € / 10 Milligramm


Voraussichtlicher Liefertermin 27-06-2019
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Beschreibung

Beschreibung

Anticonvulsant. Antagonizes GluK1 (formerly GluR5) kainate receptors (IC 50 = 0.46 μM), acts as a positive allosteric modulator of GABA A receptor-mediated currents, inhibits Na v channels (IC 50 = 48.9 μM) and inhibits L-type Ca 2+ channels. Also inhibits carbonic anhydrase (CA) (K i values are 0.1 and 0.2 μM at rat CA II and CA IV respectively), which lowers intracellular neuronal pH. Deuterated analog also available. Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Spezifikation

Spezifikation

Topiramate
>99
10mg
Topiramate
339.36
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