Tocris Bioscience™ Topiramate
GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV
Marke: Tocris Bioscience™ 362010
Weitere Details : Netto-Gewicht : 0.01000kg
BeschreibungAnticonvulsant. Antagonizes GluK1 (formerly GluR5) kainate receptors (IC 50 = 0.46 μM), acts as a positive allosteric modulator of GABA A receptor-mediated currents, inhibits Na v channels (IC 50 = 48.9 μM) and inhibits L-type Ca 2+ channels. Also inhibits carbonic anhydrase (CA) (K i values are 0.1 and 0.2 μM at rat CA II and CA IV respectively), which lowers intracellular neuronal pH. Deuterated analog also available. Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
For Research Use Only