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Thermo Scientific Chemicals U-73122, 95 %

Catalog Number 15465189
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Menge:
1 mg
5 mg
10 mg
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112648-68-7
C29H40N2O3
1-[6-[((17beta)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]pyrrole-2,5-dione
Dieser Artikel kann nicht zurückgegeben werden. Rückgaberichtlinie anzeigen
112648-68-7
C29H40N2O3
1-[6-[((17beta)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]pyrrole-2,5-dione

It is used as a phospholipase C, phospholipase A2, and 5-LO inhibitor. It is also determined that in SK-N-SH neuroblastoma cells, U-73122 inhibits agonist-induced down-regulation of muscarinic receptors. In addition, it is a useful tool to investigate receptor-mediated PI turnover in signal transduction. U-73122 is a potent inhibitor of human neutrophil adhesion to biological surfaces (IC50 = 50 nM) as well as adhesion-dependent granule exocytosis and oxidative burst. U-73343 (sc-201422) is useful as a negative control for investigations of U-73122 phospholipase C antagonism and its cellular consequences.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Hemmt die Phospholipase C-Aktivierung und Runterregulierung von muskarinischen Rezeptoren.
TRUSTED_SUSTAINABILITY
Menge 1 mg
Beschreibung Off-white
Zur Verwendung mit (Anwendung) Hemmt die Phospholipase C-Aktivierung und Runterregulierung von muskarinischen Rezeptoren
Formelmasse 464.65g/mol
Löslichkeit Soluble in DMSO, ethanol, or DMF at approx. 0.5mg/ml; May require heating or overnight mixing; Insoluble in water
Produkttyp Signal Transduction Reagent
Form Kristalliner Feststoff
Assay ≥99%

RUO – Research Use Only

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